Mod 4 add

• C1AAD

  • Disopyramide
  • Quinidine
  • Procainamide
  • CE: Decrease conduction velocity
  • MOT: Na channel inhibition
• C2AAD

  • Propranolol
  • Metoprolol
  • Atenolol
  • CE: Heart block
  • MOT: B-adrenergic receptor inhibition
• C3AAD

  • Amiodarone
  • Sotalol
  • CE: Increase duration of action potential
  • MOT: K channel inhibition
• C4AAD

  • Diltiazem
  • Verapamil
  • CE: Decrease AV conduction
  • MOT: Ca channel inhibition
• Cardiac glycosides

  • Digoxin
  • CE: Decrease AV conduction
  • MOT: Na, K-ATPase inhibition
• Catechol glycosides

  • Epinephrine
  • Isoproterenol
  • Norepinephrine
  • CE: Tachycardia
  • MOT: B-adrenergic stimulation
• Aminoglycosides

  • Gentamycin, Kanamycin, Streptomycin, Tobramycin
  • CE: Negative Inotropy
  • MOT: Decrease Ca influx
• Fluoroquinolones

  • Ciprofloxacin, Levofloxacin, Moxifloxacin
  • CE: Increase AP duration
  • MOT: K channel inhibition
• Macrolides

  • Azithromycin, Clarithromycin, Erythromycin
  • CE: Increase AP duration
  • MOT: K channel inhibition
• Antifungal

  • Amphotericin B
  • CE: Negative Inotropy
  • MOT: Ca channel inhibition
• Antihistamine

  • Astemizole, Terfanadine
  • CE: Increase AP duration
  • MOT: K channel inhibition
• Antineoplastic

  • Daunorubucin, Doxorubucin
  • CE: Cardiomyopathy
  • MOT: Oxidative stress, Apoptosis
• Antiviral

  • Zidovudine
  • CE: Tachycardia
  • MOT: Nonselective B-adrenergic receptor stimulation
• Appetite suppressants

  • Amphetamine, Fenfluramine, Phentermine
  • CE: Negative Inotropic effect
  • MOT: Ca channel inhibition
• General Anesthetic

  • Halothane, Enflurane
  • CE: Tachycardia
  • MOT: PDE inhibition
• Methylxanthine

  • Theophylline
  • CE: Tachycardia
  • MOT: Nonselective B-adrenergic receptor stimulation
• Nasal Decongestants

  • Ephedrine, PPA, Phenylephrine, Pseudoephedrine
  • CE: Tachycardia, Arrhythmia, Decrease AV conduction
  • MOT: Anti-cholinergic effects
• Phenothiazine

  • Chlor-promazine, Thioridazine
  • CE: Bradycardia
  • MOT: Ca channel inhibition
• Thyroid hormones

  • Thyroxine, Triiodothyronine
  • CE: Tachycardia
  • MOT: Altered Ca homeostasis
• TCAs

  • Amitriptyline, Desipramine, Imipramine
  • CE: ST segment elevation, QT interval prolongation
  • MOT: Na, K, Ca channel inhibition