1. Aim - to test the benefit of a hollistic approach (CBT + antidepressants) for treating people with treatment-resistant depression, compared to antidepressants alone
2. Method - 469 patients with treatment-resistant depression were randomly assigned to either usual care (just antidepressants) or usual care and CBT
3. Improvement was assessed using the Beck Depression Inventory (BDI) before and after
4. Results - after 6 months, 21.6% of usual care group and 46.1% of usual care + CBT had more than a 50% reduction in symptoms. After 12 months those having usual case + CBT continued to show greater levels of recovery
5. Conclusion - CBT + antidepressant medication is more effective in reducing depressive symptoms than antidepressant medication alone