SAMA

• Short acting muscarinic antagonists (SAMA)

  • Parasympatholytic - work against/inhibit parasympathetic nervous system, therefore inhibiting bronchoconstriction
  • Anti-muscarinics
  • Blocks release of acetylcholine at neuromuscular junction
  • Relaxation of smooth muscle
  • Max effect 30 – 60 minutes
  • Trade name – Atrovent
  • Drug name – Ipratropium Bromide
  • Used more in COPD than asthma