Development and Course of Pica. Onset can occur in childhood, adolescence, or adulthood, although childhood onset is the most commonly reported. It can occur normally developing children, whereas in adults it appears more likely to occur in the context of intellectual developmental disorder or other mental disorder. The course of the disorder can be protracted and can result in medical emergencies (intestinal obstruction, acute weight loss, poisoning). The disorder can be potentially be fatal depending on substances ingested.