Herpes

• Herpes is the only virus with a tegument
• HSV-1: cold sores, skin infections
• HSV-2: genital herpes, STD
• Herpes is a dsDNA virus, has a capsid, tegument, and envelope
• The tegument contains 15 different proteins that assist in the translation of DNA
• Skin ulcers are filled with virus
• Herpes incubates for 3-6 days
• Herpes is productive after the infection of the upper epithelial cells
• Herpes will travel to neurons, and live in symbiosis within it.
• LAT genes help keep the neuron latent, has a circular DNA strand
• Within the neurons, the viral particles reassemble
• Antigrade transport happens to the epithelial cells
• Herpes needs both host and viral activation to replicate, so it is not spread by direct contact
• Acyclovir prevents DNA replication
• Thiamine Kinase is an enzyme that catalyzes the conversion of thiamine to thiamin pyrophosphate
• Herpes is latent within the neuron