Alpha-2 agonist

• drug examples?

  medetomidline, dexmedetomidline, atipamezole.
• What is it used for?

  Anaesthetic pre-med and used as multi-modal analgesic approach
• What does it provide?

  sedation and analgesia.
• Advantages- characteristics of the drug?

  Dose dependent sedation, duration of action dose dependent, drug sparring effect which allows reduced dosage of induction agents.
• Advantages- physiological affects of the drug?

  Provides analgesia, muscle relaxation and visceral analgesia.
• Disadvantages- physiological affects of drug?

  Associated with cardiovascular depression which decreased cardiac output and bradycardia. hypertension, vasoconstriction, hypothermia, pale mm, vomiting, reduced intestinal motility.
• Characteristic of antagonist drug?

  reversal of sedation and analgesia
• what patients should Alpha-2 agonist be avoided in?

  CVD, liver disease or where committing would be risky.