Adenoviridae

• Adenoviridae

  • No. 1 viral cause of conjunctivitis 
  • Naked icosahedral - double stranded linear DNA 
  • Unusually stable to chemical or physical agents
  • Adverse pH conditions
  • Allow prolong survival outside the body 
  • Causes upper and lower respiratory diseases 
  • Pharyngitis /rhinitis  (sore throat) 
  • Conjunctivitis (pink eyes - epidemic keratoconjunctivitis) 
  • Viral 
  • Sore eyes 
  • Pneumonia 
  • Gastroenteritis in children 
  • Many infections are subclinical
• Incubation period of adeno

  2 to 14 days (For Gastroenteritis - 3 to 10 days)
• MOT of adeno

  • Droplets 
  • Fecal-oral route 
  • For poorly chlorinated water or fomites - direct
• Characteristics of adeno

  • Grapelike cluster cytopathic effect 
  • 70 nm in diameter 
  • Larger than papovaviruses

  
• Disease of Serotype 3, 4, 7, 21 of adenovirus

  acute respiratory disease (3,7-pharyngitis)
• Disease of Serotype 8, 19 of adenovirus

  Epidemic keratoconjunctivitis (conjunctivitis)
• Disease of Serotype 11, 21 of adenovirus

  Hemorrhagic cystitis
• Disease of Serotype 40, 41 of adenovirus

  Infantile gastroenteritis