Parvoviridae

• Parvoviridae

  • Parvovirus smallest DNA virus, naked - single stranded linear DNA 
  • B19 virus - causes fifth disease or Erythema infectiosum 
  • B19 virus replicate in immature erythroid cell (pronormoblast and normoblast), adult bone marrow and fetal liver 
  • Virus can stop production of RBC in the bone marrow 
  • Parvovirus B19 is classified under genus Erythrovirus 
  • Wide distribution among warm blooded animals 
  • Aplastic crisis in patients with hemoglobinopathies and fetal infections (hydrops fetalis)
• Age bracket of parvo

  4 to 12 yo
• Characteristics of parvo

  • Rashes 
  • Slapped cheek rush appearance

  
• Classic Childhood Diseases (series of rashes)

  • Rubeola (measles) 
  • Scarlet fever 
  • Rubella (3 day measles/ german measles) 
  • Duke’s disease (associated with staph aureus)
  • (S)B19 
  • Roseola Infantum (HHV-6 and HHV-7) 
  • HHV Human herpes virus