Allosteric enzymes

• allosteric enzymes


  enzymes in a pathway which can be manipulated by raising or lowering their activity, to alter the rate of product formation
• conformational change


  change in shape of a protein due to binding of a ligand
• allosteric site

  the site at which an allosteric modulator joins to the protein and causes a conformational change. different from the active site.
• what structure are allosteric proteins likely to have?


  have quaternary structure consisting of multiple sub units.
• allosteric interactions...

  occur between spatially disinct sites
• positive modulator


  increase the enzymes affinity
• negative modulator


  decreases the enzymes affinity for its substrae