ACP

• Drug examples?

  Acetylpromazine (ACP)
• What form can phenothiazines come in?

  Injectable and tablet.
• What does it provide?

  tranquilisation (calming) with sedation at high doses.
• what is it used for?

  Used as a pre-med with opioids, as it enhances each others effects.
• Advantages- characteristics of the drug?

  Smooth recovery, long duration (6hrs), safe as no coma if overdose, synergism as improves sedative effect of opioids.
• Advantages- physiological affects of drug?

  Anti-arrhythmic, anti-emetic as offsets emetic effects of some opioids like morphine. Spasmolytic as reduces discomfort when colic results from GI spasms. Anti-histamine and safe for respiratory at standard dose.
• disadvantages- characteristics of the drug?

  Unpredictable sedation, slow to peak effect 30-45 mins after I/M injection, no analgesia, long duration as is dose dependent but can be prolonged in liver dysfunction patients.
• Disadvantages- physiological effects of the drug?

  Can cause vasodilation which leads to hypotension and hypothermia. May cause syncope as excessive doses may reduce seizure threshold in epileptic patients. Poor muscle relaxation.
• Drug differing sensitivities- Patients who are sensitive?

  Boxers and giant dogs due to body size. Herding breeds require 25% reduced dose as it has prolonged affect on them.
• Drug differing sensitivities- Patients who are resistant?

  Terrier and cats.