Bad: Acne, water retention, male pattern baldness, cardiovascular effects, liver effects
Good: Used in treating disease, increase strength and lean body mass, decrease body fat, increase aggressiveness
Antibiotics
Pneumonia
HIV
MRSA
C. difficile
Sepsis
Surgical prophylaxis
Antibiotics
Common cause: Bacteria
Used to treat: Urinary/kidney infection, persistent cough, skin infections, meningitis
Prescribing medicines is the most common healthcare intervention
10,000 doses given daily in a typical hospital
Total no. of items dispensed in 2018 was 1.1 billion, up from 752 million in 2006
Processes involved in the use of medicines
Procurement
Storage
Prescribing
Preparation
Transport
Dispensing
Collection
Administration
Disposal
Legal categories of medicines
POM (prescription-only medication)
P (pharmacy)
GSL (general sales list)
Controlled drugs have greater levels of control
Medicines can be therapeutic or non-therapeutic
Appropriate polypharmacy
Prescribing for an individual for complex conditions/situations where medicine's use has been proven
Problematic polypharmacy
Prescribing multiple medicines inappropriately where the intended benefit of medicines is not clear
Adherence
Involving patients in decisions about prescribed medicines and supporting adherence
Non-adherence
Intentional: Patient decides not to follow treatment recommendations
Unintentional: Patient wants to follow but has practical problems
Estimated £90 million worth of unused prescription medications retained in individuals' homes, £110 million returned to community pharmacies, and £50 million worth of NHS-supplied medicines disposed of unused by care homes
7% of hospital admissions are due to adverse drug reactions, occurring in 10-20% of hospitalized patients and may be responsible for 1 in 1000 deaths
Sectors where medicines are managed
Community pharmacy
Hospitals
Industry
Primary care (GP, clinics, care homes)
Stakeholders involved in management of medicines
Doctors
Nurses
Pharmacists
Pharmacy technicians
Patients
Carers
Roles involved in management of medicines
Prescribe
Monitor
Administer
Supply
Store
Prepare
Advise
Educate
Counsel
Potential causes of medication errors
MORS (coding errors)
Incorrect diagnosis
Dose miscalculations
Incorrect drug administration
Lack of patient communication
Potential causes of non-adherence to medicines
Intentional: Fear of side effects
Unintentional: Capacity and resource limitations, misunderstanding, cost
GSL
General Sales List
POM
Prescription only medication
Active Ingredients
Name of active component in product, i.e. the drug