1. Action potential travels down the axon
2. Vesicles containing neurotransmitters merge with cell membrane and release neurotransmitters into synaptic cleft
3. Receptors on postsynaptic neuron's dendrite membrane detect neurotransmitters, changing the chemistry
4. If change passes threshold, new action potential is triggered
5. Neurotransmitters detach from receptors and return to presynaptic cell via transport proteins (reuptake)