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Human physiology
Movement
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Musculoskeletal system
Roles: movement, support, protection
Bone
Rigid nature supports and protects organs
Provides structure for muscles to pull and create movement
Movement
1. Muscles contract
2. Muscles pull on tendons
3. Tendons attached to bones
4. Bones act as levers
Antagonistic muscles
Muscles that work in opposite directions to produce controlled movement
Antagonistic muscles in insect leg
Extensor tibiae muscle (extends leg)
Flexor tibiae muscle (flexes leg)
Skeletal muscles work in antagonistic pairs
Synovial joints allow certain movements but not others
Skeletal muscle fibres
Multinucleate
Contain specialized endoplasmic reticulum
Muscle fibres
Contain many myofibrils
Myofibril
Basic rod-like contractile unit within a muscle cell
Sarcomere
Contractile unit of a myofibril
Muscle contraction
Sliding of actin and myosin filaments
ATP hydrolysis
Necessary for filaments to slide
Calcium ions, tropomyosin, troponin
Control muscle contractions
Fluorescent calcium indicators and dyes used to study rapid muscle contraction
Ashley and Ridgway first studied role of calcium ions in muscle contraction using aequorin