Holistic and preoccupied medicine centred on only interpreting changes in the humours and no required knowledge of the anatomy. It viewed health as the sound balance of the humours, imbalance too much or too little of one of them, or an imperfect quality produced disease. Excretion is disease - sweat, phLego, urine, vomit, diarrhoea- were interpreted as the products of natural defence mechanisms to restore balance.