CC TDM PT 2

• Major cardiac glycoside

  DIGOXIN
• Function of Digoxin is it Alters the force of contraction through its effect on the ATPase pump in heart muscle
• What does digoxin inhibit?

  Na-K ATPase
• Used as treatment of patients with Congestive Heart Failure (CHF)

  Digoxin
• Digoxin is excreted as digoxigenin in the urine
• Therapeutic range of digoxin

  0.8-2 ng/ml
• Half life of digoxin

  38 hours
• Peak assessment of digoxin is conducted after 8 hours of oral dosage
• Measurement is through immunoassay
• What ANTIARRHYTHMIC DRUGS is used to correct heart beat?

  Lidocaine
• Lidocaine is also known as?

  Xylocaine
• Lidocaine is metabolized in the liver
• Therapeutic range of LIDOCAINE?

  1.5-4.0 ug/ml
• If toxic range is more than 8 ug/mL?

  Severe Decrease in BP

  Cardiac output
• How is Lidocaine measured?

  Chromatography

  Immunoassay
• Naturally occurring drug

  QUINIDINE
• myocardial depressant that decreases the heart's ability to conduct current

  QUINIDINE
• Therapeutic Range of Quinidine

  2-5 ng/mL
• Peak Assessment Quinidine sulfate

  After 2 hours
• Peak Assessment Quinidine gluconate

  After 4-5 hours
• Measurement of Quinidine 


  Chromatography

  Immunoassay
• Quinidine is used as supplemental therapy wit digoxin
• used to treat inappropriate ventricular contractions and tachycardia

  procainamide
• Peak assessment for procainamide

  1 hour
• Stabilizes the heartbeat/cardiac arrhythmia

  DISOPYRAMIDE
• DISOPYRAMIDE is eliminated by the?

  Renal system
• Prescribed for

  ➢ atrial and ventricular arrhythmias

  ➢ hypertension

  PROPRANOLOL
• It is considered to be a beta-blocker.

  PROPRANOLOL
• Inhibitor of protein (CHON) synthesis

  AMINOGLYCOSIDES
• AMINOGLYCOSIDES - Used to treat infections caused by gram-negative bacteria.
• ROA of aminoglycosides?

  IV and IM
• Elimination of aminoglycosides is through kidney filtration
• Disrupts the inner cochlea of the ear and vestibular membranes, hearing and balance impairment.


  Ototoxicity
• What type of drug is Aminoglycosides?


  Antibiotic
• What type of drug is Vancomycin?


  Antibiotic
• Used to treat infections caused by gram-positive bacteria.


  VANCOMYCIN
• Vancomycin is Used to treat infections caused by gram-positive bacteria.
• Vancomycin is an Effective treatment for MRSA
• Which antibiotics has poor git absorption?

  Aminoglycosides and vancomycin
• ROA of Vancomycin?


  IV