Haemoproteins

• HbA Adult 


  alpha 2 beta 2
• HbF Foetal 


  alpha 2 gamma 2
• HbA2 Minor Adult 


  alpha 2 delta 2
• HbS sickle cell anaemia

  alpha 2 betaS2
• alpha globin genes


  located on chromosome 16
• beta globin genes 


  located on chromosome 11
• P50 value 


  measures the strength of binding to oxygen
• Myoglobin P50 value 


  1 Torr
• Haemoglobin P50 value 


  26 Torr
• haemoglobinopathies


  normal amounts of defective globin subunits (qualitative defects)
• thalassaemia


  abnormal amounts of normal globin defects (quantitative defects)
• Haemoglobin M 


  proximal histidine residue replaced by Tyrosine
• Haemoglobin S 


  amino acid substitution on the exterior of the beta-globin subunit
• alpha thalassaemia 


  too little of alpha globin chains
• beta thalassaemia 


  too little of beta globin chains
• the Bohr effect 


  the inter-relationship between the binding of O2, H+ and CO2 in haemoglobin