CRF

• Altered hematologic functions


  Anemia, Bleeding tendencies, Infection
• Impaired GI functions

  • Mucosal Ulcerations
  • Stomatitis
  • Parotitis
  • Gingivitis
  • Esophagitis
  • Gastritis
  • Colitis
  • GI Bleeding
  • Diarrhea
  • Constipation
  • Anorexia
  • Nausea
  • Vomiting
• Altered Respiratory Functions


  • Dyspnea
  • Pulmonary edema
  • Uremic pleuritic
  • Labored breathing
  • pleural effusion
  • Uremic lung
  • Cough reflex is depressed
• Cardiovascular Changes


  • HTN lead to HF
  • Retinopathy
  • Encephalopathy
  • Nephropathy
  • Dysrhythmia
  • Peripheral Edema
  • Uremic Pericarditis
• CNS Impairments


  • Agitation
  • lethargy
  • delirium
  • forgetfulness
  • attention deficit
  • short attention span
  • impaired reasoning
  • fluctuating mood
  • hallucinations
  • coma
• Musculoskeletal Changes


  • Osteomalacia
  • Osteitis Fibrosa
  • Osteoporosis
  • Osteosclerosis
• Integumentary Changes


  • Yellow gray discoloration of skin
  • pale, dry and scaly skin
  • pruritus
  • bruising
  • petechial and Purpura
  • Brittle hair
  • Nails are thin and brittle
• Reproductive Changes


  • [Women] Menstrual irregularities, infertility, decreased libido
  • [Men] Impotence, testicular atrophy, oligospermia, decreased libido, decreased sperm motility
• Endocrine Changes


  • Hypothyroidism
  • increased Growth Hormone and prolactin
• Immunologic Changes


  • Depression of antibody formation
  • decreased leukocytes functions
  • depression of delayed hypersensitivity
• Psychosocial Changes


  • Personal and behavioral changes
  • withdrawal
  • depression
  • anxiety
  • decreased ability to concentrate
  • lack of mental focus
• Long-Term impact of CRF on Patients


  • Physical
  • Familial
  • Spiritual
  • Social
  • Economical
  • Emotional Disturbance
• Long-Term impact on Carer for Patients with CRF


  • Physical
  • Social
  • Psychological
  • Emotional