modular exam mod 6

• Quality


  • Conformance to specifications
  • Everybody's business
  • Totality of product features that bears on its capacity to satisfy specifications
• Quality management


  Part of GMP concerned with sampling, specification & testing, documentation & release procedures to ensure necessary & relevant tests are performed and product is released only after ascertaining quality
• Hemolysin


  Enzyme which produces complete hemolysis
• Ethylene oxide


  Colorless, poisonous gas used for low temperature sterilization like the gas sterilization
• Antoni Van Leeuwenhoek


  First to observe accurately, record, and report the presence of microorganisms, thus, was named as the father of protozoology and bacteriology
• Prontosil


  One of the earliest antimicrobial drugs and is used for hemolytic streptococcal infection and is part of the sulfonamide group
• Pasteurization is a partial sterilization of a product like milk or wine to make it safe for consumption and improve its keeping quality
• Mycobacterium tuberculosis


  Discovered by Robert Koch
• Joseph Lister


  • First to formally challenge the accepted belief of spontaneous generation
  • Father of antiseptic surgery
  • Found a way to prevent infection in wounds during and after surgery
  • Advanced the idea of antisepsis in health care settings by using phenol to sterilize surgical instruments and clean wounds
• Routes of administration of Pen G


  • Deep IM
  • IV
  • IM and IV
• Penicillin


  Belongs to the Beta – lactam antibiotic class and is widely used to manage and treat a widely range of bacterial infection
• Monera is not a eukaryote
• Prokaryotes


  Store their DNA in the cytoplasm
• Cocci


  Bacteria that are spherical in shape
• Volumetric solution


  Solution of known concentration that is used to react with the analyte
• Equivalence point


  When an equal number of moles of reactant and moles of analyte have reacted, the reaction has reached a point called the equivalence point which is also known as the theoretical point or stoichiometric point
• Distilled water


  Type of water wherein all the contaminants and minerals have been removed by means of vaporization of water followed by condensation in a purer state. It is typically used in the laboratory as a solvent for reagent preparation
• Water for Injection


  Must not contain an antimicrobial
• Toluene moisture apparatus


  Method II of water content determination involves the use of this apparatus, where toluene or xylene may serve as an alternative
• Characteristics of Gram positive bacteria


  • Has simple cell wall
  • Thin peptidoglycan
  • No outer lipopolysaccharide wall
  • Retain iodine and appears purple
• Coagulase test


  Biochemical test that differentiates pathogenic Staphylococcus aureus and Staphylococcus epidermidis
• Positive result for Coagulase test

  Clotting of plasma
• Incidence


  The number of people in a population who develop a disease during a particular time period
• Emulsion


  Irreversible changes that may occur when placed under stress include sedimentation, creaming, and breaking
• Sterility test is not typically performed for final product quality control assessment of sterile dosage forms
• Zeta potential


  The measure of the difference in potential between the dispersion medium and the dispersed phase, or as the electrostatic repulsive forces between particles in a suspension
• Personnel


  Element of a production line considered to pose the greatest risk for product contamination
• Aristotle


  Introduced the Theory of Spontaneous Generation
• Bacteriology


  Field of science that studies bacteria
• Phenolphthalein, Methyl red, Methyl orange


  Best choice of indicators when reacting a weak acid with a strong base in aqueous solution
• Diluting acids


  It is important to add water to acid
• Gram-equivalent weight


  The mass of a substance, in grams, that combines with or displace a fixed quantity of another substance or is chemically equivalent to one gram-atomic weight (1.008 grams) of hydrogen. It may be calculated by dividing the atomic or molecular weight by the valence
• Indicator


  Organic weak acids that have different colors in their acid and conjugate base forms and thus serve the purpose of indicating the endpoint of a titration reaction
• Reduction-Oxidation titration


  Titration reaction involving a loss and/or gain of electrons
• Positive result for Catalase test

  Bubble formation
• Dick test


  Laboratory test designed to indicate whether or not a person is immune to scarlet fever
• Quellung test


  Test used to identify capsules of Streptococcus pneumoniae
• Toxic shock syndrome


  • Not characterized by exfoliation
• Staphylococcus aureus


  Produces golden yellow pigments
• Streptococcus pyogenes


  Can cause scarlet fever characterized by bright red tongue