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• free living amoeba:

  Acanthamoeba spp.

  Naegleria fowleri
• Granulomatous amebic encephalitis:

  Acanthamoeba spp.
• cause Amebic keratitis in contact lens wearers:

  Acanthamoeba spp.
• Cysts have double walled wrinkled cyst, 1 nucleus and large karyosome

  Acanthamoeba spp.
• Trophozoites ore pleomorphic; small nucleus with large central karyosome

  Acanthamoeba spp.
• identify this parasite, cyst form (L) troph form (R): Acanthamoeba spp.

  
• cutaneous or pulmonary:


  Acanthamoeba spp.
• cause hematogenous dissemination to brain:

  Acanthamoeba spp.
• can be cultured on lawn of bacteria (E. coli)

  Acanthamoeba spp.
• Primary amebic meningoencephalitis


  Naegleria fowleri
• Trophozoites ore found in CSF or in meninges and surrounding brain tissue


  Naegleria fowleri
• 10-35 um trophozoites, small nucleus with a large, dense central karyosome

  Naegleria fowleri
• enters through the nasal cavity and travels to the frontal lobe of the brain:

  Naegleria fowleri
• It is one of the causes of a serious infection of the brain called granulomatous amebic encephalitis (GAE):

  Balamuthia mandrillaris