bioinorg

• salvarsan


  syphilis
• lithium carbonate and lithium 


  mood disorder
• cis-diamminedichloroplatinum (II)


  Cisplatin
• year cisplatin synthesized


  1884
• year cisplatin approved as drug

  1978
• octahedral


  Pt IV
• coordination chemistry, oxidation states, good stability


  what makes metals special
• Iron oxidation states


  2+ and 3+
• Ferroportin


  only protein that can export iron from cells
• hepcidin


  hormone for iron absorption
• ceruloplasmin

  oxidizes Fe2+ to Fe 3+
• Acquired

  Anemia
• Genetic

  Atransferrinemia
• Atransferrinemia

  absence of ferroportin
• Iron overload

  hemochromatosis
• 'bronze diabetes'

  Hemochromatosis
• secondary hemochromatosis

  external factors (frequent blood transfusion)
• Copper is absorbed in

  small intestine (Duodenum and proximal jejunum)
• where does copper bind?

  albumin
• primary storage site for copper

  liver
• excess copper is taken by

  hepatocytes (liver cells)
• where hepatocytes bind?


  metallothionein
• excretion of copper


  bile
• copper deficiency


  Menkes syndrome
• Menkes is caused by


  mutation of ATP7A
• Copper overload


  Wilson's disease
• Normal Cu uptake daily

  2-5 mg
• Wilson's disease symptom


  Kayser-Fleischer ring
• Zinc chelating therapy


  EDTA and DTPA
• EDTA meaning


  ethylenediaminetetraacetic acid
• DTPA meaning


  diethylenetriaminepentaacetic acid
• Zinc has role in _ signaling

  insulin
• zinc associated deficiency


  liver fat increase
• Zn deficiency in insulin resistance


  can impair insulin sensitivity, lead to elevated blood sugar
• Acrodermatitis Enteropathica


  disrupts intestinal zinc absorption
• Zinc toxicity acute symptoms 


  nausea, vomiting, diarrhea
• Zinc toxicity chronic symptoms

  Cu deficiency
• mechanism following brain ischemia

  zn overload
• brain ischemia


  halted blood flow