Influenza

Cards (22)

  • Influenza is an ssRNA virus
  • FLu A: leads to epi and pandemics, has animal reserviours
  • Flu B: can lead to epidemics, no animal reservoirs
  • Flu C: minor respiratory dosease
  • Hemaggluination binds to the polysaccharide chains with sialic acid residues
  • Influenza residues determines to what receptors it binds to
  • Influenza attachment binds to sialic acid on glycoproteins
  • flu incubates for 1-3 days
  • Flu infects epithelial cells in the respiratory tract
  • Flu is transmitted by sloppily making out with people (aerosols)
  • Flu has malaise, non-productive cough
  • Amantidine and Rimantidine prevent uncoating
  • Zanamivir is an NA inhibitor
  • Antigenic drift: change in H and N proteins, gradual over time
  • Antigenic shift is the recombination of viruses
  • Flu incubation is 1-3 days
  • FLu recovery is 1 week
  • Flu reasons incubates in the upper respiratory
  • Flu destroys epithelial and mucus secreting cells
  • FLu virus spreads into the lower respiratory tract
  • FLu causes the shedding and necrosis of lung epithelial cells
  • Immune response causes the trigger of interferon and lymphokine release