Endocrine Adrenal Gland

• Hyperaldosteronism is treated with spironolactone
• Drugs for tre addison disease

  Hydrocortisone 2/3 morning 1/3 afternoon

  fludrocortisone
• Mineralocoticoid 


  Fludrocortisone

  Trimcinolone
• Drug for Diagnosis of cushing syndrome 


  Dexamethasone
• Cortcosteroids are not curative in the inflammatory disorders
• Treatment of Allergic rhinitis

  beclomethasone fluticasone and mometasone
• Acceleration of lung maturation


  Betamethasone and dexamethasone

  IM to mother
• • Treatment of
  • cerebral edema
  • collagen diseases
  • malignancies

  Dexamethsone
• Corticosteroid Drug preferred in pregnancy 


  Prednisone
• large doses of corticosteroids are required for more than 2 weeks suppression of the HPA axis occurs
• the most common adverse effect of corticosteroids 


  Osteoporosis
• Increased appetite is not necessarily an adverse effect In fact it is one of the reasons for the use of prednisone in cancer chemotherapy
• Antifungal drug and inhibitor of adrenocorticoid

  Ketoconazole
• It is used in the treatment of pateint with Cushing syndrom

  Ketoconazole
• inhibits the synthesis of glucocorticoids by inhibitng the 11β-hydroxylase

  enzyme that catalyzes the Enal step in the glucocortcoid pathway

  Metyrapone
• use in tests of adrenal function and for preparing patients for surgery

  Metyrapone
• antihypertensive drug and inhibito of adrenocorticoid competes for the mineralocorticoid receptor and thus inhibits sodium reabsorptiob

  Spironolactone
• management of hirsutism and antiandrogen on hair follicle

  Spironolactone
• binds to the mineralocorticoid receptor

  acts as analdosterone antagonist so avoid gynecomastia

  Eplerenone