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  • The human cardiovascular system
    • Ability to divert blood during diving
    • Different pressures in the two circuits
    • Pressure drops at capillaries
  • The heart contracts and relaxes rhythmically

    1. Valves open and close
    2. Cardiac cycle consists of two main phases
  • Ventricles
    Right and left ventricles have different thickness (muscle mass)
  • Heart valves
    • Atrioventricular (AV) valves maintain unidirectional blood flow between atria and ventricles
    • Semilunar (SL) valves ensure one-way flow out of the ventricles to the arterial systems
  • LV contracts with a greater force than RV, but both ventricles pump the same volume of blood
  • Cardiac output (CO)

    Volume of blood pumped by each ventricle per minute
  • Cardiac output
    Depends on heart rate and stroke volume
  • SA node
    Generates electrical impulses in atria and sets the rate of heart contractions
  • AV node

    Relays signals from SA node to ventricles and triggers ventricular contractions
  • An electrocardiogram (ECG/EKG) detects electrical impulses in the heart and can provide data about heart health
  • Arteries
    • Transport blood from heart to lung and other tissues
    • Have the thickest wall of all the vessels
    • Outer layer of connective tissue with elastic fibers
    • Layer of smooth muscles controlled by hormones/neurons
  • Capillaries
    • Have a single layer of epithelial cells wrapped in ECM
    • Diameter barely permits passage of RBCs
  • Veins
    • Transport blood from the lung and other tissues to the heart
    • Have thinner walls than arteries
    • Large veins have valves to ensure blood flow toward the heart
    • Have lower blood velocity and pressure than arteries
  • Blood pressure

    The force that blood exerts against the wall of blood vessels
  • During systole
    Elastic walls of arteries stretch, resulting in systolic pressure
  • During diastole
    Elastic arteries snap back, resulting in diastolic pressure
  • Mean arterial pressure
    Cardiac output x Total peripheral resistance
  • Blood velocity
    The speed with which blood flows forward through a given segment of the circulatory system
  • Blood velocity
    Inversely proportional to the total cross-sectional area of all vessels at any given level of the circulatory system
  • Arterioles and precapillary sphincters

    • Regulate the flow of blood into capillaries
  • Regulation of blood flow

    • Relaxation of precapillary sphincters in digestive tract after meal
    • Increased blood flow to muscles during exercise
    • Regulation of blood flow to skin to control body temperature
    • Increased blood flow to sites of infection or injury
  • Exchange between capillaries and interstitial fluid
    Occurs through diffusion, endocytosis/exocytosis or through pores
  • Blood pressure
    Forces fluid and small solutes out of the capillary at the arterial end
  • Osmotic pressure

    Draws in fluid at the venous end, because the blood has a higher concentration of solutes than the interstitial fluid
  • Edema
    Tissue swelling caused by excessive accumulation of interstitial fluid
  • Components of blood
    • Red blood cells
    • White blood cells
    • Plasma
  • Anemia
    Abnormally low amounts of hemoglobin or a low number of red blood cells, causing fatigue due to lack of oxygen in tissues
  • Erythropoietin (EPO)

    Stimulates the bone marrow to produce more red blood cells
  • Blood clotting
    Blood contains self-sealing materials that are activated when blood vessels are injured
  • The human cardiovascular system

    • Ability to divert blood during diving
    • Different pressures in the two circuits
    • Pressure drops at capillaries
  • The heart contracts and relaxes rhythmically

    1. Valves open and close
    2. Cardiac cycle consists of two main phases
  • Ventricles
    Right and left ventricles have different thickness (muscle mass)
  • Heart valves

    • Atrioventricular (AV) valves maintain unidirectional blood flow between atria and ventricles
    • Semilunar (SL) valves ensure one-way flow out of the ventricles to the arterial systems
  • LV contracts with a greater force than RV, but both ventricles pump the same volume of blood
  • Cardiac output (CO)

    Volume of blood pumped by each ventricle per minute
  • Cardiac output
    Depends on heart rate and stroke volume
  • SA node
    Generates electrical impulses in atria and sets the rate of heart contractions
  • AV node

    Relays signals from SA node to ventricles and triggers ventricular contractions
  • An electrocardiogram (ECG/EKG) detects electrical impulses in the heart and can provide data about heart health
  • Arteries
    • Transport blood from heart to lung and other tissues
    • Have the thickest wall of all the vessels
    • Outer layer of connective tissue with elastic fibers
    • Layer of smooth muscles controlled by hormones/neurons