Requires close monitoring including regular blood levels. Therapeutic levels are between 0.5-1.2 (1.0-1.5 in acute mania). Blood levels can become elevated in dehydration, profuse sweating and chronic diarrhea leading to toxicity. Toxicity can cause tremors, confusing, seizures, coma, and even death. Early warning signs of toxicity include; nausea, vomiting, sedation