Skin - flushed, itching, or burning, especially over the face and upper part of the chest; urticaria (hives), edema, pallor, cyanosis
Circulatory system - dilated peripheral blood vessels, increased vessel permeability, drop in blood pressure, weak and barely palpable pulse
Respiratory system - sneezing or itching in the nasal passages, stridor, upper airway obstruction, tightness in the chest, with a persistent dry cough, wheezing and dyspnea (difficulty breathing), secretions of fluid and mucus into bronchial passages, alveoli, and lung tissue, causing coughing; constriction of bronchi; difficulty drawing air into the lungs; forced expiration, requiring exertion and accompanied by wheezing, cessation of breathing
Other - abdominal cramping, nausea, vomiting, altered mental status, dizziness, fainting and coma