Immunology

• Secondary response


  • More extensive and prolonged
  • Memory cells are ready to go!
• Primary response


  1. Takes time to develop

  2. Antigens activate B cells

  3. Plasma cells differentiate

  4. Antibody titer—level of antibodies in plasma

  
• Antibody tier


  • Slowly rises
  • Peaks
  • Can take two weeks to develop
  • Declines rapidly
• IgM


  • Produced faster than IgG
  • Less effective than IgG
• Secondary response


  1. Activates memory B cells

  2. At lower antigen concentrations than original B cells

  3. Secrete antibodies in massive quantities

  
• IgG


  • Rises very high and very quickly
  • Can remain elevated for extended time
• IgM in secondary response


  Production is also quicker
• Immunocompetence before birth


  Maternal IgG antibodies pass through placenta

  
• Immunocompetence after birth


  Mother's milk provides IgA antibodies