Immunology (2)

• Mononuclear phagocytes


  1. Circulate in blood for 8 hours

  2. Migrate into tissues

  3. Differentiate
• NK cells


  Large lymphocytes
• NK cells


  • First line of defense against viruses
  • Target and kill infected cells
  • Produce various cytokines
• Major types of dendritic cells


  • 4
• Dendritic Cells


  • Perform antigen capture
  • Perform antigen presentation
  • Perform T cell activation
  • Can produce ROS
  • Can produce interferons
• Major cell groups of adaptive immunity

  • B lymphocytes
  • T lymphocytes
• B lymphocytes

  • Mature in bone marrow
  • B cell receptor is a membrane bound antibody
  • Memory cells have a longer lifespan
  • Plasma cells produce antibodies
  • First encounter of antigen - divides rapidly into memory and plasma cells
• T lymphocytes

  • Bone marrow derives but matures in thymus
  • Express T-cell receptor on membrane
  • In response to specific antigens, lymphocytes proliferate
• Both B and T lymphocytes undergo clonal selection
• Plasma (effector) cells


  Short lived
• Mononuclear phagocytes

  1. Circulate in blood for 8 hours

  2. Migrate into tissues

  3. Differentiate
• NK cells


  Large lymphocytes
• NK cells


  • First line of defense against viruses
  • Target and kill infected cells
  • Produce various cytokines
• Major types of dendritic cells

  • 4
• Dendritic Cells


  • Perform antigen capture
  • Perform antigen presentation
  • Perform T cell activation
  • Can produce ROS
  • Can produce interferons
• Major cell groups of adaptive immunity

  • B lymphocytes
  • T lymphocytes
• B lymphocytes


  • Mature in bone marrow
  • B cell receptor is a membrane bound antibody
  • Memory cells have a longer lifespan
  • Plasma cells produce antibodies
  • First encounter of antigen – divides rapidly into memory and plasma cells
• T lymphocytes


  • Bone marrow derives but matures in thymus
  • Express T-cell receptor on membrane
  • In response to specific antigens, lymphocytes proliferate
  • Plasma (effector) cells are short lived
  • Memory cells – long lived but don't take part in the initial immune reaction but respond to the second encounter
• Both B and T lymphocytes undergo clonal selection