RNA VIRUS

• CORONAVIRIDAE is single stranded RNA genome, helical capsid envelops
• Coronaviruses are a large family of viruses causing a range of illnesses, from the common cold to more serious infections such as those caused by Middle East Respiratory Syndrome-related Coronavirus (MERSCoV) and Severe Acute Respiratory Syndrome-related Coronavirus (SARS-CoV).
• HUMAN CORONAVIRUS NAME: SARS-CoV-2 ILLNESS: COVID-19
• HUMAN CORONAVIRUS NAME: SARS-CoV (SARS) ILLNESS: Severe acute respiratory syndrome
• HUMAN CORONAVIRUS NAME: MERS-CoV (MERS) iLLNESS: Middle East Respiratory Syndrome
• CORONAVIRIDAE infects EC of URT, grows best at 33°C to 35°C
• TYPES OF POLIOVIRUS: Asymptomatic illness, Abortive poliomyelitis or minor illness, Non paralytic poliomyelitis or aseptic meningitis, Paralytic polio or major illness
• 85% that causes polio is type 1
• POLIO Vaccine associated are type 2 or type 3
• Herpangina- Disease caused by coxsackie A virus
• Hand-Foot-and-Mouth disease - caused by Coxsackievirus A16 and enterovirus 71 Pleurodynia
• Hand-Foot-and-Mouth disease → Coxsackievirus A16 and enterovirus 71 Pleurodynia → Coxsackie B virus
• Pleurodynia - caused by Enterovirus D68
• Myocardial and pericardial infections → Coxsackie B virus (B3)
• Viral meningitis → Coxsackievirus or echovirus
• Herpangina → occurring among children, these are small blister in mouth and throat.
• BORN HOLM DISEASE- Pain on inspiration is similar to pleuritic pain and pulmonary embolism may be suspected. The muscles are locally tender.
• BORN HOLM DISEASE - It is upper respiratory infection due to coxsackie B virus in young adult, followed by pleuritic chest pain, upper abdominal pain with tender muscles.
• ORTHOREOVIRUS - AKA. Mammalian reovirus, Fecal-oral transmission, Infect upper respiratory or GI (acid stable), Usually asymptomatic not significant source of disease.
• Rotavirus → People with AIDS can also have this virus
• Rotavirus - Infantile diarrhea
• ORBIVIRUS - African horse sickness
• ORBIVIRUS - Blue tongue – sheep
• ORBIVIRUS - Epizootic hemorrhagic disease – deer
• REOVIRIDAE – Respiratory Enteric Orphan Viruses
• 4 picornaviridae: enterovirus, rhinovirus, cardiovirus, aphtovirus
• Orbivirus is a genus of double-stranded RNA viruses in the family Reoviridae and subfamily Sedoreovirinae. Unlike other reoviruses, orbiviruses are arboviruses.
• RUBELLA VIRUS - A benign febrile viral disease with LNE
• RUBELLA VIRUS - Little red in Latin, Teratogenic → Congenital infection → German measles → Incubation period 2-3 weeks
• Rash – discrete maculopapular rash, starts on forehead & face and spread down o Rash typically lasts for -3 days
• Genus Alphavirus → Arbovirus
• Genus Rubivirus → Rubella Virus
• Genus Flavivirus → Arbovirus
• West Nile virus (WNV) is the leading cause of mosquito-borne disease in the continental United States. → It is most commonly spread to people by the bite of an infected mosquito.
• The Bunyaviridae are divided into arthropod-borne viruses (arboviruses) and rodent-borne viruses (roboviruses).