In colonial Latin America, the Catholic Church played a multifaceted role as a dominant religious, social, and political institution. At the forefront of the European encounter with the Americas, the Church embarked on a mission of evangelization, sending missionaries to convert indigenous populations to Catholicism. This endeavor, however, often resulted in cultural syncretism, as indigenous beliefs and practices blended with Christian traditions. The Church established schools, orphanages, and hospitals, contributing significantly to education and social services in the colonies. Despite these positive contributions, tensions arose over the encomienda system, where the Church grappled with conflicting interests. Figures like Bartolomé de las Casas emerged, advocating for the protection of indigenous rights and condemning the exploitation and forced labor imposed by Spanish colonizers. While some within the Church defended indigenous populations, others were complicit in the economic benefits derived from colonial practices. Thus, the Catholic Church in colonial Latin America was a complex institution, simultaneously involved in cultural preservation, education, and social welfare while grappling with internal conflicts over its role in colonial administration and the treatment of indigenous peoples.