Lung (5)

• Total lung capacity


  Vital capacity + residual volume
• Factors influencing O2 binding to haemoglobin


  • Acidity
  • Bohr effect
  • Partial pressure of CO2
  • Temperature
  • BPG ( 2, 3 bisphostphateglycerate)
• Central chemoreceptor


  • Increase firing with Medulla oblongata
  • Detects protons in the cerebrospinal fluid
  • Increase PCO2
  • Brain ECF PCO2
  • Increase H+
• Peripheral chemoreceptor


  • Increase firing with Aortic bodies
  • Carotid bodies
  • Decrease arterial PCO2
  • Increase in non-co2 acids via H+
  • Increase in arterial PCO2 via H+
• Lung diseases


  • Obstructive diseases
  • Restrictive diseases