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123: Medicinal Chemistry
Unit 9
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Incisor
Cutting
and
biting
Main
Functions of the Teeth
Chewing
food into a
bolus
Gives structure,
tissue support
and
shape
to the face
Aid in the
pronunciation
of
sound
during speech
Crown
Part of the
tooth
above the
gum
Neck
Part of the tooth at the
gum line
Root
Part of the tooth
below
the gum
Enamel
Outermost
layer of the tooth
Dentin
Layer under the enamel
Odontoblasts
Cells
that produce
dentin
Pulp
Chamber
Contains
blood vessels
and
nerves
Gum
Soft tissue
covering the
jaw
bone
Root Canal
Passage through the
root
of the
tooth
Cementum
Covers the
root
of the tooth
Periodontal
Ligament
Connects the tooth to the
jaw
bone
Blood Vessels
Supply the tooth with
nutrients
Jaw
Bone
Supports
the
teeth
Root
Apex
Tip
of the tooth
root
Common
Dental Problems
Gingivitis
Periodontitis
Halitosis
(bad breath)
Tooth
erosion
and
decay
Mouth sores
Unattractive smile
Classification
of Dental Products
Anticaries
Agents
Cleaning
Agents
Desensitizing
Agents
Polishing
Agents
Dental
cement
and
fillers
Anticaries
Agents
Agents that
prevent
tooth
decay
Tooth
decay process
1.
Bacteria
feed on sugars
2.
Bacteria
make
acid
3.
Acid
damages tooth surfaces
4. Over time, this process can cause a
hole
Plaque
Dental biofilm
that forms on teeth
Tooth
decay process
1.
Sugars
in drinks and foods
2.
Bacteria
in plaque
3.
Acids
4.
Demineralisation
(loss of calcium and phosphate)
Fluoride
An anticariogenic agent that replaces the hydroxyl ion in hydroxyapatite with the
fluoride
ion to form fluorapatite in the outer surface of the
enamel
Fluorapatite
Hardens
the enamel and makes it more
acid resistant
Sodium Fluoride (NaF)
Protects teeth from
acid
demineralization, provides
strength
for tooth enamel, prevents dental caries
Stannous
Fluoride (SnF2)
Unpleasant
astringent-salty
taste, should be freshly prepared as aqueous solution deteriorates
rapidly
Acidulated Phosphate Fluoride
Prevents
dental
caries, reduces
gum
and tooth sensitivity, strengthens teeth
Mechanical
measures to control dental caries
Prophylaxis
by dentist
Tooth
brushing
Mouth rinsing
Use of
dental floss
or tooth picks
Incorporation
of detergents foods in diet
Pit
and
fissure
sealants
Cleaning
Agents (Dentrifice)
Clean tooth surface, provide
polishing
effect, physically remove plaque and debris,
whiten
teeth
Cleaning
Agents
Calcium salts
such as carbonate, phosphate and pyrophosphate
Sodium salts
such borate, metaphosphate
Hydrogen
peroxide and magnesium peroxide
Ammoniacal silver nitrate solution
Desensitizing
Agents
Reduce sensitivity of teeth to
heat
,
cold
or touch, provide local anesthetic, non-abrasive
Desensitizing
Agents
Zinc chloride
Strontium chloride
Pumice
A light, rough, porous, odorless, greyish mass that contains silicates of
aluminum
,
potassium
and sodium
Polishing Agents
Clean tooth surface, provide
polishing
effect,
whiten
teeth
Polishing
Agents
Sodium metaphosphate (
SMP
)
Pumice
Dental
cement and fillers
Temporarily cover and protect teeth that have undergone
dental
procedure or surgery, can contain
antiseptic
or local anaesthetic
Dental cements and fillers
Zinc oxide eugenol
Zinc oxide +
zinc chloride
Zinc oxide +
phosphoric acid
=
zinc oxychloride, zinc oxyphosphate
Categories
of Inhalants by NIH
Volatile solvents
Aerosols
Gases
Nitrites
Volatile
solvents
Liquids that
vaporize
at room temperature, common household, industrial and
medical
products
Gases
Common
household
, industrial and
medical
products
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