Competitive inhibitors have a similar shape to that of the substrate molecules and therefore compete with the substrate for the active site
Non-competitive inhibitors bind to the enzyme at an alternative site, which alters the shape of the active site and therefore prevents the substrate from binding to it
Inhibitors
Slow down or stop enzyme activity
Increasing the concentration of an inhibitor
Reduces the rate of reaction
Increasing the inhibitor concentration further
The reaction will stop completely
Competitive inhibitors
Countering the increase in inhibitor concentration by increasing the substrate concentration can increase the rate of reaction once more (more substrate molecules mean they are more likely to collide with enzymes and form enzyme-substrate complexes)
Non-competitive inhibitors
Increasing the substrate concentration cannot increase the rate of reaction once more, as the shape of the active site of the enzyme remains changed and enzyme-substrate complexes are still unable to form
