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• therapeutic platlet- pheresis is performed to remove granulocytes and platelets
• therapeutic plasmapheresis is performed to remove plasma
• The most common cause for transfusion during the neonatal period, especially if they are born before 34 weeks, is anemia.
• Hyperkalemia can result from transfusion of a large number of stored units of red blood cells.
• When there is blood loss, the body attempts to correct the decrease in intravascular fluid volume by shifting fluid and protein from the extravascular spaces.
• Irradiated blood is recommended for exchange transfusion in order to:

  Decrease the incidence of graft versus host disease
• Postpartum Mom: Anti-D Neg, Rh Control Neg, WkD Pos, 20 rosettes/5 fieldsBaby: Anti-D 4+, Rh control Neg

  Mother displays a fetal-maternal hemorrhage, give Rh immune globulin
• Which of the following antigens is most likely to be involved in hemolytic disease of the newborn?

  Jk(a)
• A Group A, Rh positive baby of a group O, Rh positive mother has a weakly positive DAT and moderately elevated bilirubin at birth. The most likely cause is:

  ABO incompatibility
• What type of testing may be performed on a prenatal OB patient with a confirmed, identified antibody, to monitor status during gestational period?

  Antibody titer
• Which of the following antibodies is NOT associated with HDFN?

  Anti-Le(a)
• An unexplained decrease in hemoglobin and mild jaundice in a patient transfused with red blood cells one week ago would likely indicate:

  delayed hemolytic transfusion reaction
• Fever, chills, hemoglobinuria, hypotension, and generalized bleeding are symptoms of which of the following transfusion reactions:

  hemolytic
• The component best suited for a patient with IgA deficiency and has had several anaphylactic transfusion reactions in the past is:

  Red Blood Cells, washed
• A single unit of platelets collected by pheresis should have a minimum of:

  3.0 x 10^11 plt
• The most effective component to treat a patient with a fibrinogen deficiency is:

  Cryoprecipitated AHF
• To demonstrate whether antibodies have become attached to a patient's red cells in vivo, one would perform:

  a direct antiglobulin test.
• To eliminate pseudo-reactivity caused by rouleaux:

  Add saline to the test system
• Polyspecific anti-human globulin reagents must contain adequate levels of which of the following?

  IgG and complement
• The following immediate spin reactions are from Patient Jones:Anti-A 0, Anti-B 0, Anti-A,B 0, A1 cells 0, A2 cells 0, B cells 0, O cells 0, Auto 0

  Group O in an elderly patient, incubate at room temp
• The following reactions are from Patient Smith:Anti-A 2+, Anti-B 0, Anti-A,B 2+, A1 cells 1+, A2 cells 0, B cells 4+, O cells 0, Auto 0What is the most probable explanation for these reactions?

  Group A2 with Anti-A1 antibody
• Factor V deficient patient that is pregnant and scheduled for C-section the next day

  needs fresh frozen plasma
• 68 year old with heart failure and anoxia secondary to iron deficiency anemia (IDA)

  needs red blood cells
• 4 year old with subacute lymphocytic leukemia and much bruising and a 11.0 g/dL hemoglobin

  needs platelets
• Classic hemophiliac with bleeding into joints with a 12.0g/dL hemoglobin

  needs cryoprecipitated AHF
• Different methods of antibody screening: tube testing, GEL, and Solid Phase, have different levels of sensitivity.
• Blood samples must be labeled with at least 2 patient identifiers, date and time of collection, and a way to identify the phlebotomist.
• Ficin (enzyme) treatment of red cells will destroy which of the following antigens?

  fya
• Which of the following would not be performed as part of routine pre-transfusion testing?

  Full antigen typing and DAT
• Mixed field reactions can be associated with the following:

  recently transfused patient, subgroups of A or B, and bone marrow transplant patients
• An agglutination reaction described as 2-3 large sized clumps with a clear background would be graded as:

  3+
• A patient has a history of anti-K from 2003. The current specimen does not demonstrate any antibodies, and the antibody screen test is negative. Blood for transfusion should be:

  K negative and crossmatch compatible
• Of the antibodies below, which one does NOT fit with the others in terms of optimal temperature of reactivity?

  Anti-E
• Which of the following antibodies characteristically react ONLY at the AHG phase of testing?

  Anti-Fya, -Jka, and -K(Duffy, Kell, Rh, Kidd, Ss)