Endocrine and ANS work in parallel during a stressful event. The hypothalamus activates the pituitary gland and this triggers activity in the sympathetic branch of the ANS. ANS changes from parasympathetic state to the physiologically aroused sympathetic state. Adrenaline is released from the adrenal medulla into the bloodstream. This triggers physiological changes in the body which creates physiological arousal necessary for fight or flight. This response is immediate and automatic. There is an increased heart rate, breathing rate, pupils dilate, inhibits digestion, saliva production and contracts the rectum. Once the threat has passed, the parasympathetic nervous system returns the body to its resting state. The actions of the parasympathetic are antagonistic to the sympathetic nervous system.