Huntington's (HTT)

• Huntington's disease is a progressive neurodegenerative disorder that affects the brain and spinal cord
• The allele coding for Huntington's is dominant
• If an individual has over 40 CAG repeats, they will develop symptoms of Huntington's
• phenotypical features:

  • gradual development with age
  • no symptoms until the person is 30-40 years old
  • Individuals begin to lose their ability to walk and control movements along with talking and thinking clearly
  • Huntington's is fatal, with death occurring within the first 15 - 20 years of first symptoms appearing