AUTOIMMUNITY, DEF. OF IMMUNE SYSTEM, IMMUNOPROLIFERATIVE DSE

• conditions in which damage to organs/tissues results from the presence of autoantibody/autoreactive cells

  Autoimmunity
• Organ specific autoimmune disease

  Hashimoto’s thyroidits, Grave’s disease
• Systemic autoimmune disease

  SLE
• lab features of SLE

  presence of ANAs, ↓ complement level
• FANA – Fluorescent ANA is aka as _ _

  Indirect Immunofluorescence
• Gives rise to appearance of LE cells; found in 90% of cases w/ untreated SLE

  Anti-DNP
• Associated w/ SLE and Sjogren’s syndrome

  Anti-La (SS-B)
• Found in cases of SLE, RA, Sjogren’s syndrome,

  Anti-RNP
• SLE, Mixed Connective Tissue Disease, CREST syndrome

  Anti-centromere
• anti-dsDNA's gold standard

  IFA staining of Crithidia luciliae
• Parallels disease activity of SLE

  anti-dsDNA
• Anti-histones are found in cases of _-_ _

  Drug-induced lupus
• Anti-Ro (SS-A) are found in cases of _ / _ _

  Cutaneous / Neonatal SLE
• Found almost exclusively (marker) in patients w/ SLE

  anti-Sm
• SLE, Sjogren’s syndrome, Systemic sclerosis

  Anti-nucleolar RNA
• have Finely speckled pattern

  Anti-Ro (SS-A), Anti-La (SS-B)
• have Coarsely speckled pattern

  Anti-Sm, Anti-RNP
• have Diffuse / homogenous or Peripheral / rim pattern

  Anti-dsDNA. Anti-DNP
• have Diffuse / homogenous pattern

  Anti-histones
• have Discrete, speckled pattern

  Anti-centromere
• have Nucleolar pattern

  Anti-nucleolar RNA
• [OTHER AUTOIMMUNE DISEASES] Sjogren’s syndrome

  anti-salivary & anti-lacrimal glands
• [OTHER AUTOIMMUNE DISEASES] anti-TSHr

  Grave’s disease
• [OTHER AUTOIMMUNE DISEASES] anti-glomerular basement membrane

  Goodpasture’s syndrome
• [OTHER AUTOIMMUNE DISEASES] Multiple sclerosis

  anti-myelin basic protein
• [OTHER AUTOIMMUNE DISEASES] Myasthenia gravis

  anti-acetylcholine receptor
• [OTHER AUTOIMMUNE DISEASES] anti-mitochondrial

  Primary Biliary Cirrhosis
• [OTHER AUTOIMMUNE DISEASES] anti-smooth muscle

  Chronic active hepatitis
• [OTHER AUTOIMMUNE DISEASES] anti-thyroglobulin

  Hashimoto's disease
• [OTHER AUTOIMMUNE DISEASES] Rheumatoid Arthritis

  Rheumatoid Factor & anti-CCP
• [OTHER AUTOIMMUNE DISEASES] Type I DM

  anti-islets cells
• [OTHER AUTOIMMUNE DISEASES] Pernicious anemia

  anti-parietal cells
• [OTHER AUTOIMMUNE DISEASES] anti-centromere Abs

  Scleroderma / CREST
• usually seen in adults, well-differentiated cells, usually not curative

  CLL
• ALL – usually seen in _, _ differentiated cells, _

  children, poorly, treatable
• Hodgkin’s disease = presence of

  Reed-Sternberg cells
• B cell lymphoma represent the majority

  Non-hodgkin disease
• [B-CELL SYSTEM DEFECTS] most common congenital immunodeficiency; susceptible to respiratory or GI infections

  Selective IgA Deficiency
• [B-CELL SYSTEM DEFECTS] In IgG Subclass Deficiency, the most common deficiency is

  IgG4
• [B-CELL SYSTEM DEFECTS] characterized by deficiency of both IgA and IgG antibodies

  Common Variable Immunodeficiency