Ab STRUCTURE & FUNXN, CYTOKINE, COMPLEMENT, HYPERSENSITIVITY

• _ has receptor for phagocytes;

  CH2
• CH3 has receptor for _ (_)

  Complement, C1q
• _ – monomer – found in _

  IgA1, serum
• _ - “reaginic antibody”

  - “heat - _ antibody”

  IgE, labile
• IgA2 – _ – found in _

  Dimer, secretions
• antibody production = antibody degradation

  Plateau
• exponential phase and has increase antibody

  Log, production
• increased antibody degradation

  Decline
• no antibody is produced

  Lag
• Fragmentation of Monomer

  Papain, Pepsin
• Fragmentation of IgM

  DTT, 2-ME
• Papain have _ fragments

  3
• Pepsin have _ fragments

  2
• [IgG subclasses] fixes complement

  IgG1, IgG2, IgG3
• [IgG subclasses] cross placenta

  IgG1, IgG3, IgG4
• Surface immunoglobulin found on B cells that is used for Immunoregulation

  IgD
• Immunoglobulin that is found mostly in intravascular pool; the most primitive among Igs

  IgM
• IgM is most efficient in _ and _ _

  Agglutination, Complement fixation
• Major antibody in 2° Immune Response

  IgG
• Major antibody in 1° Immune Response

  IgM
• Has shorter lag phase

  Secondary Immune Response
• small soluble proteins regardedbas chemical messengers; orchestrating both innate immunity and advaptive respone to infection

  Cytokines
• flexible portion of anibody; located bet. CH1 and CH2; rich in amino acid proline

  Hinge region
• flexible portion of anibody; located bet. CH1 and CH2; rich in amino acid proline

  Hinge region
• Disulfide bonds have two types: _ bonds and _ bonds

  Intrachain, Interchain
• region or section of antibody molecule

  Domain
• 2 types of Domain

  Variable region and Constant region
• 2 identical Heavy chains is compsed of

  gamma, mu, alpha, epsilon, delta
• 2 identical Light chains is composed of

  kappa, lambda
• Domain that is responsible for placental transfer

  Constant region / Carboxy-terminal end
• Variable region / Amino-terminal end is for _ _ site

  Antigen binding
• IgG %

  70-75 %
• Sedimentation of IgM

  19s
• Immunoglobulin that has the longest half-life? _ days

  IgG, 23
• Immunoglobulin that has the shortest half-life? _ days

  IgE, 2.5
• Immunoglobulin that has the highest MW? _ da

  IgM, 900,000
• Immunoglobulin that crosses placenta

  IgG
• Immunoglobulin in Complement Fixation

  IgG, IgM
• IgA dimer = _, IgA monomer =

  IgA2, IgA1
• [CYTOKINES] pro-inflammatory; helps in Ig synthesis

  IL-6