TYPES OF IMMUNITY, LYMPHOCYTES & LYMPH ORGAN, MHC

• Early stages of T cells

  CD5 and CD7
• Cytotoxic/Suppressor T cell

  CD8
• “E-rosette” receptor

  CD2
• Helper / Inducer T cell

  CD4
• found on all stages of B cells

  CD20
• found mostly on mature B cells

  CD22
• part of T-cell antigen receptor

  CD3
• early stages of B cells / CALLA

  CD10
• receptor for C3d and EBV

  CD21
• part of B cell coreceptor

  CD19
• receptor for IgG

  CD16
• Mitogens of B-cells

  Staphylococcal Protein A, Pokeweed
• Mitogens of T cells

  Phytohemagglutinin, Concanavalin A, Pokeweed
• Substances that coat particles & organisms to make them more susceptible to phagocytosis - Ex. CRP, C3b, antibodies


  Opsonins
• normal serum constituents that increase by at least 25% due to infection, injury, or trauma to tissues; produced primarily by _.

  Acute Phase Reactants, hepatocytes
• surface receptors that promote cell to cell interaction

  Integrins
• [Phagocytosis] release of enzymes from granules; respiratory burst occurs via oxidative metabolism

  Digestion
• [Phagocytosis] migration of phagocytes from the blood vessels (capillaries) to the injured tissue

  Diapedesis
• [Phagocytosis] made possible thru TLRs found on surface of phagocytes

  Initiation
• [Phagocytosis] outflowing of cytoplasm occurs and formation of phagosome

  Engulfment
• Celullar component of 3rd Line of Defense

  B cells and T cells
• Humoral component of 2nd Line of Defense

  Complement system (major component), Interferons
• Humoral component of 3rd Line of Defense

  Antibodies – IgG, IgA, IgM, IgD, IgE; Cytokines
• Cellular component of 2nd Line of Defense

  Phagocytic cells (major component), Antigen Presenting Cells, NK Cells
• Lymphocyte that has Antibody-Dependent & Cellular Cytotoxicity as Immunity

  NK cells
• Immunity of T cells

  Cell-mediated
• Immunity of B cells

  Humoral mediated
• [SPLEEN] _ _ _ produces T cells

  Periarteriolar Lymphoid Sheath
• Lymphoid organ that acts as a lymphatic filter; it's the major site of antibody production

  Spleen
• main functions is filtration of lymphatic fluid

  Lymph nodes
• Maximum size at birth and undergoes physiologic atrophy as we age

  Thymus
• [MATURATION STAGES] rearrangement of genes coding for TCR ; (-) CD4 and CD8 (+) _, _, _

  DOUBLE NEGATIVE STAGE, CD2, CD5, CD7
• [MATURATION STAGES] appearance of surface IgM and IgD

  Mature B cell
• [MATURATION STAGES] responsible for production of antibodies, Oval in shape, eccentric nucleus, “cartwheel-like” nuclear chromatin, has perinuclear hof

  Plasma cell
• [MATURATION STAGES] Plasma cell surface markers

  CD38, CD138
• [MATURATION STAGES] (+) CD3, CD4, CD8

  DOUBLE POSITIVE STAGE
• [MATURATION STAGES] rearrangement of genes coding for: Heavy chain - encoded on chromosome _ ; Light chain - encoded on chromosome _ and _

  Pro-B cell, 14, 2, 22
• [MATURATION STAGES] either CD4 or CD8 is present

  Mature T cell
• [MATURATION STAGES] apperance of CD25

  Activated B cell / Activated T cell
• [MATURATION STAGES] CD25 is the receptor for

  IL-2