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Cards (485)
Pharmacognosy
Applied science that deals with the
biological
,
biochemical
and economic features of drugs or biological origin and their constituents
Crude drugs
Plant exudates
Natural substances
No
molecular modification
had been made
Derivatives or extractives
Chief
principles
or constituents of crude
drugs
Solvent
/
menstruum
Liquid
or
liquid
mixture
Marc
Undissolved
portion
Indigenous plants
Native
countries
Naturalized
plants
Foreign land
Rinorea niccolifera
Metal eating plant (more on
nickel
)
Geographic source &
Habitat
Region in which the plant or
animal
yielding the drug
grows
Infusion
Hot water (ex. Tea); short contact action -
3-5
minutes only
Maceration
Soaked in
solvent
for long periods of time
Percolation
Filtering of fluids through porous materials; passage through
percolate
(ex. Simple Syrup USP)
Digestion
Not boiling (
low heat
); <35 -
40⁰
C
Decoction
Boiling
water
Liquid-Liquid Extraction
1.
Portioning
2.
Distillation
Distillation
Purifying liquid by
heating
and
cooling
Collection
Small scale
Improper collection results to
partial
or
complete
substitution
Collection time -
Flower
- best to harvest at
dawn
Bark -
spring
and
summer
Root crops - when
upper ground
portion is about to
wither
Harvesting
Large
scale
Manual
labor
vs.
mechanical
devices
Mechanical
devices: pickers, mowers, binders, swath, steel
Manual
- for potent constituents
Drying
Air
drying and
artificial
drying
Prevent
bacterial
,
fungal
growth and enzymatic degradation
Facilitates
grinding
and
milling
Curing
- special drying process
Garbling
Final step in the preparation of crude drugs
Removal of
extraneous
matter (other parts of the plant, dirt, added adulterants)
Packaging, storage & preservation
To avoid insect attacks: Expose drug to
65°c
Fumigation with
methyl bromide
Add a drop of
chloroform
or
carbon tetrachloride
Evaluation of Drugs
Quality
(inherent/descriptive in nature) and
purity
Qualitative
and
quantitative
assays
Quality
- intrinsic property of drug; type of medicinal principles
Quantity
- amount
Organoleptic/Morphological evaluation
1. Evaluate
macroscopic
appearance of drug:
Shape
2.
Size
3.
Color
4.
Fracture
&
internal
color
5.
Odor
6.
Taste
Microscopic evaluation
1.
Identity
and
purity
of the drug substance
2.
Adulterant
can also be detected microscopically
3.
Staining techniques
and
reagents
Pharmacologic evaluation
1.
Preclinical
or
Bioassay
2.
Living organism
or their
isolated living tissues
are used
3.
Antibiotics
, toxins and toxoids and
vitamins
Chemical evaluation
1.
Qualitative
and
quantitative
determination of their active principles
2.
Assay
- titration is the best method for determining official potency
3.
Preliminary Phytochemical Screening
Physical
evaluation
1.
Physical characteristic
or parameters with the use if physico-chemical techniques
2. Solubility, sp. Gr.,
optical rotation
, congealing point, refractive index,
melting point
Classification of Drugs
Morphology
Taxonomy
Pharmacologic
Chemical
Alphabetical
Constituent
Mixture of substance
Secondary plant substance
Extracted
,
crystallized
and purified
Inert
matter
Active Constituent
Secondary
metabolites
Isolated
constituent that is either
pharmacologically
active or pharmaceutically active
Pharmaceutically active
Cause chemical changes in the preparation
Pharmacologically active
Responsible for the
therapeutic
activity
Inert constituents
No definite pharmacologic activity
Drug Biosynthesis/Biogenesis is Influenced by
Ontogeny
or Stage of
Development
(stage of development)
Heredity
(genetic composition)
Environment
(soil, climate, associated flora and method of cultivation)
Biosynthesis of Glycosides
1.
Condensation
products of
sugar
and the acceptor unit called as aglycone
2.
Sugar phosphates
+
uridine triphosphate
(UTP) → uridine diphosphate sugar complex
3.
Uridine diphosphate sugar complex
+ acceptor units →
glycoside production
Glycosides and their biosynthesis
Anthracene glycosides
Phenol Glycosides
Steroid Glycosides
Flavonoid Glycosides
Cyanogenetic Glycosides
Thioglycosides
/
Isothiocyante Glycosides
Saponin Glycosides
Aldehyde Glycosides
Biosynthesis of Phenylpropanoids
Shikimic Acid
biosynthetic pathway → phenylalanine and tyrosine →
phenylpropanoids
Phenylpropanoids
Phenolic
in character; devoid of
nitrogen
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