MODULE 2

Cards (485)

  • Pharmacognosy
    Applied science that deals with the biological, biochemical and economic features of drugs or biological origin and their constituents
  • Crude drugs

    Plant exudates
  • Natural substances
    No molecular modification had been made
  • Derivatives or extractives
    Chief principles or constituents of crude drugs
  • Solvent / menstruum
    Liquid or liquid mixture
  • Marc
    Undissolved portion
  • Indigenous plants
    Native countries
  • Naturalized plants

    Foreign land
  • Rinorea niccolifera
    Metal eating plant (more on nickel)
  • Geographic source & Habitat
    Region in which the plant or animal yielding the drug grows
  • Infusion
    Hot water (ex. Tea); short contact action - 3-5 minutes only
  • Maceration
    Soaked in solvent for long periods of time
  • Percolation
    Filtering of fluids through porous materials; passage through percolate (ex. Simple Syrup USP)
  • Digestion
    Not boiling (low heat); <35 - 40⁰ C
  • Decoction
    Boiling water
  • Liquid-Liquid Extraction
    1. Portioning
    2. Distillation
  • Distillation
    Purifying liquid by heating and cooling
  • Collection
    • Small scale
    • Improper collection results to partial or complete substitution
    • Collection time - Flower - best to harvest at dawn
    • Bark - spring and summer
    • Root crops - when upper ground portion is about to wither
  • Harvesting
    • Large scale
    • Manual labor vs. mechanical devices
    • Mechanical devices: pickers, mowers, binders, swath, steel
    • Manual - for potent constituents
  • Drying
    • Air drying and artificial drying
    • Prevent bacterial, fungal growth and enzymatic degradation
    • Facilitates grinding and milling
    • Curing - special drying process
  • Garbling
    • Final step in the preparation of crude drugs
    • Removal of extraneous matter (other parts of the plant, dirt, added adulterants)
  • Packaging, storage & preservation
    • To avoid insect attacks: Expose drug to 65°c
    • Fumigation with methyl bromide
    • Add a drop of chloroform or carbon tetrachloride
  • Evaluation of Drugs
    • Quality (inherent/descriptive in nature) and purity
    • Qualitative and quantitative assays
    • Quality - intrinsic property of drug; type of medicinal principles
    • Quantity - amount
  • Organoleptic/Morphological evaluation
    1. Evaluate macroscopic appearance of drug: Shape
    2. Size
    3. Color
    4. Fracture & internal color
    5. Odor
    6. Taste
  • Microscopic evaluation
    1. Identity and purity of the drug substance
    2. Adulterant can also be detected microscopically
    3. Staining techniques and reagents
  • Pharmacologic evaluation
    1. Preclinical or Bioassay
    2. Living organism or their isolated living tissues are used
    3. Antibiotics, toxins and toxoids and vitamins
  • Chemical evaluation
    1. Qualitative and quantitative determination of their active principles
    2. Assay - titration is the best method for determining official potency
    3. Preliminary Phytochemical Screening
  • Physical evaluation

    1. Physical characteristic or parameters with the use if physico-chemical techniques
    2. Solubility, sp. Gr., optical rotation, congealing point, refractive index, melting point
  • Classification of Drugs
    • Morphology
    • Taxonomy
    • Pharmacologic
    • Chemical
    • Alphabetical
  • Constituent
    Mixture of substance
  • Secondary plant substance
    • Extracted, crystallized and purified
    • Inert matter
  • Active Constituent
    • Secondary metabolites
    • Isolated constituent that is either pharmacologically active or pharmaceutically active
  • Pharmaceutically active
    Cause chemical changes in the preparation
  • Pharmacologically active
    Responsible for the therapeutic activity
  • Inert constituents
    No definite pharmacologic activity
  • Drug Biosynthesis/Biogenesis is Influenced by
    • Ontogeny or Stage of Development (stage of development)
    • Heredity (genetic composition)
    • Environment (soil, climate, associated flora and method of cultivation)
  • Biosynthesis of Glycosides
    1. Condensation products of sugar and the acceptor unit called as aglycone
    2. Sugar phosphates + uridine triphosphate (UTP) → uridine diphosphate sugar complex
    3. Uridine diphosphate sugar complex + acceptor units → glycoside production
  • Glycosides and their biosynthesis
    • Anthracene glycosides
    • Phenol Glycosides
    • Steroid Glycosides
    • Flavonoid Glycosides
    • Cyanogenetic Glycosides
    • Thioglycosides/Isothiocyante Glycosides
    • Saponin Glycosides
    • Aldehyde Glycosides
  • Biosynthesis of Phenylpropanoids
    Shikimic Acid biosynthetic pathway → phenylalanine and tyrosine → phenylpropanoids
  • Phenylpropanoids
    Phenolic in character; devoid of nitrogen