There is evidence to support the role of some neural mechanisms in OCD. For example, antidepressants that only alter levels of serotonin have been effective in reducing OCD symptoms.
This suggests that the serotonin system is involved in OCD.
However, many people with OCD are also depressed. This co-morbidity may mean that the depression may involve disruption to the serotonin system and this may be the true cause of the OCD.