HYPERSENSITIVITY

• Immediate / Anaphylactic type of hypersensitivity

  Type 1
• Antibody Involved in Type 1 Hypersensitivity

  IgE
• Remember that in Type I: IgE antibodies and Mast cells (effector cell) or Basophils are involved
• Used to measure the total IgE in the serum of a patient

  RIST (Radioimmunosorbent Test)
• Used to determine the IgE that is directed against a specific allergen

  RAST (Radioallergosorbent Test)
• Also known as Cytotoxic hypersensitivity

  Type 2
• What are the antibodies involved in Type 2 HS?

  IgG and IgM
• anti-glomerular basement membrane antibody.

  Good Pasture Syndrome
• anti acetylcholine receptor.

  Myasthenia Gravis
• This type 2 test is Also known as the Antiglobulin test

  COOMBS’ TEST
• Immune Complex hypersensitivity reaction

  Type 3
• Cell Mediated / Delayed Type Hypersensitivity

  Type 4
• This type of Hs has no antibodies involved

  Type 4
• Gold Standard for contact dermatitis

  Skin Patch Test
• Atopic dermatitis is what type?

  Type 1
• Contact dermatitis is what type?

  Type 4
• SLE is what type?

  Type 3
• HDN is what type?

  Type 2
• This test is used to determine exposure to M tuberculosis, M-TB antigen

  Tuberculin / Mantoux / PPD Test
• HIV positive and recent contact w active TB patient

  >5mm
• Tuberculin test: Recent arrivals (<5 years) from high-prevalence countries

  >10mm
• Tuberculin test: Persons with no known risk factors for TB.

  >15mm
• NADPH oxidase Deficiency; PHAGOCYTE CELL FUNCTION DISORDER

  CHRONIC GRANULOMATOUS DISEASE
• Test for CGD 


  Nitroblue tetrazolium
• Genetic mutation leading to CD 18 Deficiency

  LEUKOCYTE ADHESION DEFICIENCY
• LYST gene mutation


  CHEDIAK-HIGASHI SYNDROME
• most common complement deficiency

  C2 deficiency
• BRUTON X-LINKED HYPOGAMMAGLOBULINEMIA; What deficiency?

  Complement and B Cell Deficiency
• Most common deficiency in Dysgammaglobulinemia

  IgA deficiency
• HLA-B8 what autoimmune disease?

  Myasthenia Gravis
• HLA-B27

  Ankylosing Spondylitis
• HLA-B7 and HLA-DR2

  Multiple sclerosis
• HLA-DR4

  Rheumatoid Arthritis
• HLA-DR3

  SLE
• HLA-DR5


  Hashimoto’s Thyroiditis