1. No improvement with treatment
3. Constipation that lasts a long time (Adults >2 weeks, Children >1 week)
4. Black, red, tarry or bloody stools can indicate underlying condition (e.g. gastric ulcer)
5. Continuous feeling of tiredness (Anaemia suspect)
6. Medication suspected induced (Opioids, Antidepressants (TCAs, SSRIs), Iron supplements)
8. Unexpected weight and appetite loss (carcinoma-suspect)
9. Weight gain, coarse hair, lethargy, dry skin (hyperthyroidism-suspect)
10. Failed treatment (Pregnant women-unless advised by GP/Nurse to purchase)