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Hematology
Primary Hemostasis Blood Vessels
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Created by
Revelyn Villaruz
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Cards (56)
Tunica intima/interna?
Simple squamous endothelium
tunica media (thickest)?
smooth muscle
and
elastic fibers
tunica adventitia/externa?
fibrous connective
tissue
distributing BV that leave the heart?
arteries
(4um)
thickest
collecting BV that return to the heart?
veins
(5 um)
venules
transport between blood and tissue?
capillaries
(8 um)
thinniest
platelet
inhibitor and vasodilator?
prostacyclin/PGI2
penetrates platelets and binds at its IP receptor?
platelet inhibitor
responsible for vasodilator?
adenosine
metabolic product of ATP and ADP?
vasodilator
Thrombin cofactor: Free Thrombin activates factors 1, 5, 8, 13?
thrombomodulin
inactivates factors 5a and 8a?
activated protein
C
anti-fibrinolytic
enzyme?
activated
TAFI
(
thrombin activatable fibrinolysis
)
Thrombomodulin + thrombin activation of protein C and TAFI and glycosaminoglycan?
thrombin inhibitor
weakly enhances antithrombin?
heparan sulfate
major plasminogen activator?
TPA (tissue plasminogen activator)
cause platelet adhesion?
VWF
carrier protein for factor 8?
VWF
arise from megakaryocytes?
PLT
occurs in both primary and secondary hemostasis?
PLT
with
granular
cytoplasm?
PLT
no nuclear material?
PLT
formation of platelet plug to slow down or stop blood loss?
PLT
participate in plasma coagulation?
PLT
preserve endothelial lining of blood vessels?
PLT
life span of 9 days +/- 1 day?
plt
wright stained PBS of 7-21
cells
/
100x
field?
plt
mpv of platelets?
6.8-10.2
fl
diameter of plt?
2-4 um range;
2.5
average
systemic circulation of plt?
2/3
part of spleen in plt?
1/3
major regulator of plt production?
thrombopoietin
/
TPO
liver is produced by 70,000 daltons?
TPO
functions of TPO?
megakaryopoiesis
along with
IL-3
, 6, 11
thrombocytopoiesis
/
plt
shedding
proliferation
and
maturation
of megakaryocytes
TPO receptor site?
MPL
protein/
myeloproliferatice
leukemia protein
largest cell in the BM with size of 30-160 um and with multilobulated nucleus?
megakaryocyte
abundant granular cytoplasm?
megakaryocyte
has a <0.5 of all BM cells?
megakaryocyte
megkaryocyte is seen in microscope of results?
2-4
megakaryocytes/
10x
LPO
earlier predictor of BM recovery after chemotherapy and transplantation?
reticulated
or
stress platelets
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