Primary Hemostasis Blood Vessels

Cards (56)

  • Tunica intima/interna?
    Simple squamous endothelium
  • tunica media (thickest)?
    smooth muscle and elastic fibers
  • tunica adventitia/externa?
    fibrous connective tissue
  • distributing BV that leave the heart?
    arteries (4um) thickest
  • collecting BV that return to the heart?
    veins (5 um) venules
  • transport between blood and tissue?
    capillaries (8 um) thinniest
  • platelet inhibitor and vasodilator?

    prostacyclin/PGI2
  • penetrates platelets and binds at its IP receptor?
    platelet inhibitor
  • responsible for vasodilator?
    adenosine
  • metabolic product of ATP and ADP?
    vasodilator
  • Thrombin cofactor: Free Thrombin activates factors 1, 5, 8, 13?
    thrombomodulin
  • inactivates factors 5a and 8a?
    activated protein C
  • anti-fibrinolytic enzyme?

    activated TAFI (thrombin activatable fibrinolysis)
  • Thrombomodulin + thrombin activation of protein C and TAFI and glycosaminoglycan?

    thrombin inhibitor
  • weakly enhances antithrombin?
    heparan sulfate
  • major plasminogen activator?
    TPA (tissue plasminogen activator)
  • cause platelet adhesion?
    VWF
  • carrier protein for factor 8?
    VWF
  • arise from megakaryocytes?
    PLT
  • occurs in both primary and secondary hemostasis?
    PLT
  • with granular cytoplasm?

    PLT
  • no nuclear material?
    PLT
  • formation of platelet plug to slow down or stop blood loss?
    PLT
  • participate in plasma coagulation?
    PLT
  • preserve endothelial lining of blood vessels?
    PLT
  • life span of 9 days +/- 1 day?
    plt
  • wright stained PBS of 7-21 cells/100x field?

    plt
  • mpv of platelets?
    6.8-10.2 fl
  • diameter of plt?
    2-4 um range; 2.5 average
  • systemic circulation of plt?
    2/3
  • part of spleen in plt?
    1/3
  • major regulator of plt production?
    thrombopoietin/TPO
  • liver is produced by 70,000 daltons?
    TPO
  • functions of TPO?
    megakaryopoiesis along with IL-3, 6, 11
    thrombocytopoiesis/ plt shedding
    proliferation and maturation of megakaryocytes
  • TPO receptor site?
    MPL protein/ myeloproliferatice leukemia protein
  • largest cell in the BM with size of 30-160 um and with multilobulated nucleus?
    megakaryocyte
  • abundant granular cytoplasm?
    megakaryocyte
  • has a <0.5 of all BM cells?
    megakaryocyte
  • megkaryocyte is seen in microscope of results?
    2-4 megakaryocytes/10x LPO
  • earlier predictor of BM recovery after chemotherapy and transplantation?
    reticulated or stress platelets