Platelet Ultrastructure

• absorbs albumin, fibrinogen and other plasma proteins via endocytosis?

  glycocalyx
• Key collagen receptor?


  GP IV
• vWF and thrombin; bernard-soulier syndrome?

  GP Ib/IX/V
• key fibrinogen receptor and Glanzmann's thrombasthenia?

  GP IIb/IIIa
• Collagen, Vitronectin, Laminin, Fibronectin?

  GP Ia/IIa
• Par 1 and Par 4 are?

  thrombin
• P2Y1 and P2Y12 are?

  ADP
• TPa and TPB are?

  TXA2
• a2-andrenergenic is part of?

  epinephrine
• low affinity receptor for Ig Fc; heparin induced thrombocytopoenia (HIT)?

  (CD32) FcyIIA
• integrin helps plt bind to endothelial cells, WBC, plt?

  P-selectin (CD62)
• route for endocytosis and secretion of alpha and lysosome granules?


  Surface-connected canalicular system (SCCS)
• microtubules formed by tubulins
• microfilaments formed by actins
• flow through plasma membrane and dense granules/delta granules
• control center for platelet activation?


  Dense tubular system (DTS)
• ultrastructure that contains cyclooxygenase; condensed remnant of rough; sequester Ca and bears enzymes for platelet activation?


  DTS
• supports production of TXA2 via eicosanoid pathway?


  phospholipase A2

  cyclooxygenase

  thromboxane synthase
• support production of IP3 and DAG?


  phospholipase C
• actin filaments is resting platelet with globular + amorphous
• Increase cytoplasmic Ca there is?

  filamentous + contractile
• Intermediate filaments has?


  desmin and vimentin
• alpha granules consist of?

  50-80 plt
• alpha granules has medium-gray (osmium dye transmission)
• alpha granules participate in secondary hemostasis like plaletelet adhesion, aggregation, coagulation
• alpha granules is not in cytoplasm
• a granules has B-throboglobulin and PF-4, EGF (endothelial growth factor), PDFG (plt-derived GF), TGF-B (transforming GF-Beta)
• alpha granule membrane has P-selectin
• alpha granules and cytoplasm has fibrinogen, fibronectin, albumin, immunoglobulins, VWF, thrombospondin, Factor V
• alpha granule membrane and plasma membrane?


  Gp IIb/IIIa, Gp IV, Gp Ib/IX/V
• Dense granules has 2-7 plt
• dense granules has opaque black (osmium dye transmission)
• dense granules participate in primary hemostatsis (vasoconstrictors and agonist)
• Dense granules has "SAM PEACH"?

  serotonin (5-HT)

  ADP

  Magnesium

  Phosphate

  Epinephrine

  ATP

  Calcium

  Histamine