Module 4

• Why appraisal is important

  • to determine if a study is the best available research to a clinical question
• Elements

  • Internal Validity/Reliability: Trustworthiness
  • Clinical Importance/Impact: results of the study
  • Applicability
• The AGREE II Instrument: widely used to assess CPG
• Fetters and Tilson's

  • based on AGREE II
  • 24 items, 6 domains
• Domains of Fetters and Tilson's

  • Scope and purpose
  • Stakeholders involvement
  • Rigor or development
  • Editorial Independence
  • Clarity of Presentation
  • Attention to implementation
• Appraisal Tools for Systematic Reviews

  • CASP checklist
  • AMSTAR
  • Greenhalgh and Donald
• Appraisal Tools for RCTs

  • CASP checklist
  • CATE
  • Fetters and Tilson's