130 exam 2 manual

• transdermal drug delivery system

  • administration of drugs systemically by the application of a drug formulation on the skin.
  • TDDs can be accomplished using transdermal patches which are adhesive patches formulated with API
• patches

  • applied to skin and deliver a given dose of the drug systemically through the layers of the skin
• advantage

  • self administration is possible as well as the continuous and sustained release of the drug
  • improves patient compliance
  • avoids peak and trough drug levels
  • avoid first pass metabolism and enzymatic degradation
  • alternate route for patients who are unable to take oral medications
  • unaffected by vomiting or diarrhea
  • administration stops with patch removal
• disadvantages

  • only small lipophilic drugs can be delivered
  • must be potent drug as the patch size limits the amount delivered
  • not for high drug doses
  • adhesion varies
  • skin irritation might occur