drugs

• Nitrates

  NO donor, inc. cGMP, dephosphorylate myosin LC
• Nitrates

  • Vein & arterial dilator (more potent vein dilator)
  • Dec. preload, end-diastolic volume, wall stress, MVO2
  • Inc. dilation of coronary artery & inc. oxygen supplies
• Nitrates side effects

  • Tolerance, reflex tachycardia & cardiac contractility, headache & dizziness, orthostatic hypotension
• Calcium channel blockers, DHP groups

  • Arteriolar dilators, decreased afterload, decreased wall stress, decreased MVO2, increased dilation of coronary artery & increased oxygen supplies
• Calcium channel blockers, DHP groups side effects

  • Reflex tachycardia & cardiac contractility
• Calcium channel blockers, Non-DHP groups

  • Cardiac depressants, dec. wall stress, dec. MVO2
• Calcium channel blockers, Non-DHP groups side effects

  • Bradycardia, inc. LV end diastolic volume & inc. ejection time
• Beta Blockers

  • Decreased myocardial contractility, dec. HR, dec. renin & dec. BP, decreased MVO2
• Beta Blockers side effects

  • Bronchospastic conditions (asthma), bradycardia, inc. LV end diastolic volume & inc. ejection time