The issue with the biological explanation of gender is that it's reductionist.
This because it reduces gender down to a neurochemical level stating hormones and chromosomes influence gender.
However it underplays other explaantions like the cognitive which states gender is the result of schemas and maturation and the psychodynamic one which acknowledges childhood experiences and family interaction.
This shows that gender is more complex that just hormones and chromosomes and need to account for other factors to explain gender holistically.