A way to explain the development of behaviour in terms of a range of factors, including both biological and psychological ones. Most importantly such factors don't simply add together but combine in a way that can'tbepredicted by each one separately i.e. they interact.
schizophrenia is explained as the result of both an underlyingvulnerability (diathesis) and a trigger (stressor), both of which are necessary for the onset of schizophrenia. In early versions of the diathesis-stress model, vulnerability was genetic and triggers were psychological. Nowadays both genes and trauma are seen as diatheses, and stress can be psychological or biological in nature.
In the US there is more of a history of conflict between psychological and biologicalmodels of schizophrenia, leading to sloweradoption of an interactionistapproach, with medication without an accompanying psychological treatment being more common
In the original diathesis-stress model, diathesis (vulnerability) was entirely genetic, the result of a single
'schizogene'.
if a person does not have the schizogene then no amount of stress would lead to schizophrenia
In carriers of the schizogene,chronic stress , including the presence of a schizophrenogenic mother, could result in the development of schizophrenia