Evidence suggests that chromosomal differences lead to gender differences in the sense that they show psychological, behavioural and physiological differences.
Research to support this comes from Delsi who found that 10/11 KF sufferers had smaller frontal, temporal lobes, and superior temporal gyrus' compared to a control group and measured using MRIs and cognitive tests.
Brown et al found that 26 TN sufferers had smaller posterior cereberal and cerebella areas.
This therefore shows evidence of biological differences which supports the nature side of the debate.